Background: Cutaneous tumors and tumor-like lesions comprise a wide spectrum of benign, malignant and non-neoplastic conditions. Accurate and early diagnosis is essential for appropriate management. Fine needle aspiration cytology (FNAC) is a simple, rapid and minimally invasive diagnostic technique that can be used for the preliminary evaluation of skin lesions. Methods: The present prospective study was conducted in the Department of Pathology, JJM Medical College, Davangere, over a period of two years from July 2015 to June 2017. A total of 145 patients presenting with clinically suspected cutaneous tumors and tumor-like lesions were included in the study. FNAC was performed in all cases and the cytomorphological features were evaluated. Lesions were classified as tumor-like lesions, benign neoplastic lesions, primary malignant lesions and metastatic or recurrent lesions. Histopathological correlation was performed wherever tissue specimens were available. Results: The age of patients ranged from 1 to 80 years, with the highest number of cases observed in the 31–40 years age group. There was a male predominance with a male-to-female ratio of 1.45:1. Clinically, most lesions presented as non-ulcerative nodules (82.06%). Cytological evaluation revealed that tumor-like lesions constituted the majority of cases (64.13%), followed by benign neoplastic lesions (16.55%), primary malignant lesions (11.03%) and metastatic or recurrent lesions (8.27%). The head and neck region was the most common site of involvement. Conclusion: FNAC is a rapid, safe and cost-effective diagnostic modality for the evaluation of cutaneous tumors and tumor-like lesions. It is useful in differentiating benign from malignant lesions and can aid in the early detection of metastatic disease. When correlated with histopathology, FNAC serves as a reliable initial diagnostic tool for the management of skin lesions.
Skin tumors and tumor-like lesions constitute a heterogeneous group of pathological conditions that range from benign cystic lesions and adnexal tumors to aggressive malignant neoplasms and metastatic deposits. Accurate diagnosis of these lesions is essential for appropriate treatment and prognosis. Although histopathological examination remains the gold standard for diagnosis, minimally invasive techniques such as fine needle aspiration cytology (FNAC) have emerged as valuable tools for the preliminary evaluation of cutaneous lesions. FNAC is a rapid, safe, minimally invasive and cost-effective diagnostic method that can be performed in outpatient settings and helps in early clinical decision making [1].
Cytopathology has evolved significantly over the last century. The technique of aspiration cytology was first described in the nineteenth century and gradually developed into an important diagnostic modality in modern pathology. Early investigators demonstrated the usefulness of needle aspiration in diagnosing various diseases including neoplasms. With the advancement of
cytological techniques and better understanding of cellular morphology, FNAC has become a widely accepted diagnostic tool for evaluating tumors of different organs including the skin [2,3].
Cutaneous tumors originate from various structural components of the skin including epidermal keratinocytes, melanocytes, adnexal structures, vascular elements and neural tissues. According to the World Health Organization classification, skin tumors are broadly categorized into keratinocytic tumors, melanocytic tumors, adnexal tumors and soft tissue tumors [4]. Among these, basal cell carcinoma and squamous cell carcinoma are the most common non melanoma skin cancers worldwide [5].
Tumor-like lesions of the skin, such as epidermal cysts, trichilemmal cysts, thyroglossal duct cysts and other How to Cite: J S Manur, R K Manur, O Puvvala, “Cytomorphological Assessment of Cutaneous Tumors and Tumor-Like Lesions: A Prospective Study with Histopathological Correlation, "CME J Ger Med, Vol. 17, No.2, 2025, pp. 90-94. benign conditions, often clinically mimic neoplastic lesions. Therefore, accurate differentiation between benign, malignant and tumor-like lesions is crucial for
appropriate patient management. FNAC plays a significant role in this regard by providing valuable cytomorphological information that helps categorize lesions and guide further diagnostic or therapeutic procedures [6].
In addition to primary cutaneous tumors, the skin may also be involved by metastatic deposits from internal malignancies. Recognition of such lesions through cytological examination can provide important clues to an underlying malignancy and aid in early diagnosis of metastatic disease [7].
Despite the advantages of FNAC, certain limitations exist due to overlapping cytological features among various skin lesions. Therefore, correlation with histopathological findings is essential whenever possible to confirm the cytological diagnosis and improve diagnostic accuracy [8].
Hence, the present study was undertaken to study the cytomorphology of tumors and tumor-like lesions of the skin and to correlate the cytological findings with histopathological diagnosis wherever possible.