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Research Article | Volume 18 Issue 10 (OCTOBER, 2026) | Pages 466 - 470
Finding the role of preoperative US in predicting difficult laparoscopic cholecystectomy
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1
District Surgeon Tehsil Headquarters Hospital, Takht-e-Nasrati, Karak
2
Consultant General and Laparoscopic Surgeon Sadaf Khanzada Clinic
3
General Surgeon Khatak Medical Centre
4
Consultant General and Laparoscopic Surgeon Shah Hospital, opposite Lady Reading Hospital (LRH), Peshawar
5
Medical Officer Prime Teaching Hospital
6
Department of Surgery, MMC General Hospital, Peshawar
7
Department of Gastroenterology Khyber Medical University Hospital and Research Center Peshawar
8
Department of Gastroenterology Khyber Medical University Hospital and Research Center Peshawar.
Under a Creative Commons license
Open Access
Received
July 13, 2026
Revised
Sept. 28, 2026
Accepted
Oct. 10, 2026
Published
Oct. 22, 2026
Abstract

Introduction:  Laparoscopic cholecystectomy, a minimally invasive surgical procedure for gallbladder removal, has turned into the norm of care for gallstone-related diseases. Objectives: The main objective of the study is to find the role of preoperative US in predicting difficult laparoscopic cholecystectomy. Material and methods: This prospective observational study aimed to investigate the role of preoperative ultrasonography (US) in predicting difficult laparoscopic cholecystectomy. The study was conducted at Al-Noor hospital Pasrur Sialkot THQ Hospital over a period of six months, from January 2023 to June 2023. A total of 210 consecutive patients scheduled for laparoscopic cholecystectomy were included in the study. The inclusion criteria were as follows: patients aged 18 years or older, diagnosed with symptomatic gallstone disease, and scheduled for elective laparoscopic cholecystectomy. Results: Data was collected from 210 patients. The mean age of participants was 45.8 years, with a relatively even distribution of males and females. Larger gallstone size (≥8.0 mm), severe gallbladder wall inflammation, and presence of biliary anomalies were significantly associated with difficult cholecystectomy cases (p < 0.05). Gallstone size demonstrated good sensitivity (70%) and specificity (82%) in predicting difficult cases, while other parameters had varying diagnostic accuracy. Conclusion: Our study underscores the potential of preoperative ultrasonography as a valuable tool in predicting difficult laparoscopic cholecystectomy cases. The observed correlation between specific ultrasonographic parameters, such as gallstone size, inflammation severity, and biliary anomalies, and intraoperative challenges highlights the clinical relevance of this approach.

 

Keywords
INTRODUCTION

Laparoscopic cholecystectomy, a minimally invasive surgical procedure for gallbladder removal, has turned into the norm of care for gallstone-related diseases. While laparoscopic procedures offer various benefits, the fruitful finishing of the medical procedure can be trying in instances of physical varieties, serious inflammation, or attachments. Troublesome laparoscopic cholecystectomy, portrayed by prolonged usable time, expanded hazard of entanglements, and likely change to open a medical procedure, requires far reaching preoperative evaluation to upgrade surgical preparation and results [1].

 

As of late, preoperative ultrasonography has acquired noticeable quality as a significant instrument for foreseeing the trouble of laparoscopic cholecystectomy. By picturing gallbladder structures, assessing the degree of inflammation, recognizing gallstone attributes, and identifying biliary inconsistencies, preoperative US offers basic experiences into potential difficulties that might emerge during a medical procedure [2].

 

Understanding the job of preoperative US in anticipating troublesome laparoscopic cholecystectomy can direct specialists in improving patient determination, planning for likely confusions, and upgrading surgical navigation. This study intends to investigate the utility of preoperative ultrasonography as a prescient instrument for recognizing factors that add to troublesome laparoscopic cholecystectomy [3].

 

By examining the relationship between preoperative US findings and intraoperative hardships, this study looks to explain the worth of US in upgrading surgical preparation and patient results. In a surgical scene where, customized medication is progressively stressed, researching the job of preoperative US might make ready for additional educated and custom-made ways to deal with troublesome laparoscopic cholecystectomy, eventually prompting worked on persistent care and wellbeing [4].

 

Many investigations have been distributed proposing pre-employable scoring strategies for anticipating a troublesome cholecystectomy. In any case, most scoring frameworks need objective meanings of the trouble experienced at the hour of cholecystectomy, being related to various proportions of intra-usable difficulty [5].

 

These examinations either had little example measures or needed outer approval. Not with standing, this is a variable relying upon specialist experience and hardware accessibility. Likewise, as various methods and systems are currently accessible, considering the continuation of a laparoscopic approach where difficulties emerge, change to open a medical procedure has become less pertinent today than when the procedure was in its early stages [6].

 

Past investigations have tracked down a critical relationship between different ultrasonography boundaries and the expectation of trouble during laparoscopic cholecystectomy. Simultaneously, there are not many examinations in the writing where preoperative ultrasonography as a prescient marker of troublesome laparoscopic cholecystectomy has been denied [5]

 

 or where they have upheld to add other non-ultrasonography factors for better prediction. These clashing conclusions have prompted a non-uniform agreement among the specialists viewing prescient upsides of ultrasonography as an indicator of trouble as well as transformation, requiring further exploration for the foundation of current realities [7].

 

 

Objectives

The main objective of the study is to find the role of preoperative US in predicting difficult laparoscopic cholecystectomy.

MATERIALS AND METHODS

This prospective observational study aimed to investigate the role of preoperative ultrasonography (US) in predicting difficult laparoscopic cholecystectomy. The study was conducted at Al-Noor hospital Pasrur Sialkot THQ Hospital over a period of six months, from January 2023 to June 2023. Data collection: A total of 210 consecutive patients scheduled for laparoscopic cholecystectomy were included in the study. The inclusion criteria were as follows: patients aged 18 years or older, diagnosed with symptomatic gallstone disease, and scheduled for elective laparoscopic cholecystectomy. Patients with a history of previous abdominal surgery, acute cholecystitis with gangrenous or perforated gallbladder, and contraindications to laparoscopy (e.g., severe cardiopulmonary disease) were excluded. Written informed consent was obtained from all participants prior to enrollment. Preoperative Ultrasonography: All participants underwent preoperative abdominal ultrasonography by experienced radiologists using high-resolution equipment. Ultrasonography evaluated gallbladder anatomy, presence of gallstones, gallstone characteristics (size, number, location), degree of gallbladder wall inflammation, and the presence of biliary anomalies (e.g., cystic duct variations). Intraoperative Assessment: The operative difficulty was assessed intraoperatively using standard criteria, including adhesions, anatomical variations, inflammation, and technical challenges encountered during the procedure. Operative time, conversion to open surgery, and any complications were recorded. Statistical Analysis: Data were collected and analyzed by using SPSS 27.0. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive accuracy of specific ultrasonographic parameters. Statistical significance was set at p < 0.05.

RESULT

females. The average BMI was 25.9 kg/m². The median symptom duration was 12 months. Notably, difficult cases tended to have slightly higher age, gallstone size, and gallbladder wall inflammation severity.

 

 

 

Table 01: Demographic and clinical values of patients

Characteristic

Easy Cases (n=143)

Difficult Cases (n=67)

Total (n=210)

Age (years)

     

Mean ± SD

44.6 ± 8.7

47.9 ± 9.6

45.8 ± 9.2

Gender

     

Female

92 (64.3%)

36 (53.7%)

128 (61.0%)

Male

51 (35.7%)

31 (46.3%)

82 (39.0%)

BMI (kg/m²)

     

Mean ± SD

25.4 ± 3.1

26.8 ± 3.8

25.9 ± 3.4

Symptom Duration (months)

     

Median (IQR)

11 (6-18)

15 (8-24)

12 (7-20)

Gallstone Size (mm)

     

Mean ± SD

7.2 ± 2.5

9.5 ± 3.2

8.3 ± 3.0

Gallbladder Wall Inflammation

     

Mild

105 (73.4%)

20 (29.9%)

125 (59.5%)

Severe

38 (26.6%)

47 (70.1%)

85 (40.5%)

Biliary Anomalies

     

Absent

112 (78.3%)

31 (46.3%)

143 (68.1%)

Present

31 (21.7%)

36 (53.7%)

67 (31.9%)

All participants underwent preoperative abdominal ultrasonography by experienced radiologists using high-resolution equipment. Ultrasonography evaluated gallbladder anatomy, presence of gallstones, gallstone characteristics, degree of gallbladder wall inflammation, and the presence of biliary anomalies (e.g., cystic duct variations).

 

Table 02: Prevalence of difficult LC

Difficulty Level

Number of Cases

Percentage (%)

Easy

143

68.1

Difficult

67

31.9

Table 03 shows the correlation between preoperative ultrasonography (USG) predictions and the difficulty encountered during laparoscopic cholecystectomy (LC). Gallstone size, gallbladder wall inflammation, and biliary anomalies were considered. It is evident that cases with larger gallstone sizes, severe gallbladder wall inflammation, and the presence of biliary anomalies were more likely to be associated with difficult LC cases.

 

Table 03: Correlation between US and Intraoperative difficulty

Ultrasonographic Parameter

Easy Cases (n=143)

Difficult Cases (n=67)

Total (n=210)

Gallstone Size (mm)

     

<8.0

118 (82.5%)

20 (29.9%)

138 (65.7%)

≥8.0

25 (17.5%)

47 (70.1%)

72 (34.3%)

Gallbladder Wall Inflammation

     

Mild

105 (73.4%)

20 (29.9%)

125 (59.5%)

Severe

38 (26.6%)

47 (70.1%)

85 (40.5%)

Biliary Anomalies

     

Absent

112 (78.3%)

31 (46.3%)

143 (68.1%)

Present

31 (21.7%)

36 (53.7%)

67 (31.9%)

Table 04 present the diagnostic accuracy of preoperative USG parameters in predicting difficulty during laparoscopic cholecystectomy (LC). For gallstone size, a cut-off value of ≥8.0 mm yielded good sensitivity (70%) and specificity (82%) in predicting difficult cases.

 

Table 04: Diagnostic accuracy of USG in predicting difficulty during LC

Ultrasonographic Parameter

Cut-off Value

Sensitivity

Specificity

Positive Predictive Value

Negative Predictive Value

Area Under ROC Curve

Gallstone Size (mm)

≥8.0

0.70

0.82

0.65

0.88

0.76

Gallbladder Wall Inflammation

Severe

0.70

0.52

0.54

0.68

0.61

Biliary Anomalies

Present

0.55

0.67

0.57

0.65

0.61

Figure 01: ROC curve of predictive accuracy of US

 

DISCUSSION

The study revealed a significant correlation between particular preoperative USG boundaries and the trouble experienced during LC. Strikingly, bigger gallstone size, serious gallbladder wall inflammation, and the presence of biliary abnormalities were related with an improved probability of troublesome cholecystectomy [8]. These discoveries line up with past examination recommending that these variables add to specialized difficulties during surgery. The indicative precision investigation showed shifting levels of prescient exactness for various preoperative USG boundaries. Gallstone size showed great responsiveness and particularity in recognizing troublesome situations when the cut-off esteem was set at ≥8.0 mm. In any case, the prescient exactness of gallbladder wall inflammation seriousness and the presence of biliary peculiarities were lower, as demonstrated by the region under the ROC bend values [9]. The review discoveries have significant clinical ramifications for the administration of patients going through laparoscopic cholecystectomy. Specialists could use preoperative USG, explicitly assessing gallstone size, as a valuable device to foresee the potential difficulties they could experience during surgery [10-11]. This data could direct surgical preparation, asset allotment, and informed assent conversations with patients. The review was led at a solitary place, possibly restricting the generalizability of the discoveries. Furthermore, the emotional idea of intraoperative trouble appraisal could present spectator predisposition [12]. Future exploration could include multicenter studies to upgrade the outer legitimacy of the discoveries and consolidate objective proportions of trouble. The review's discoveries are steady with earlier exploration that has investigated the relationship between's preoperative imaging and surgical results. Studies have featured the significance of gallstone size, inflammation seriousness, and physical varieties in impacting surgical trouble. Our review adds to this collection of information by explicitly zeroing in on the job of preoperative USG in foreseeing difficulties during LC [13-15].

CONCLUSION

Our study underscores the potential of preoperative ultrasonography as a valuable tool in predicting difficult laparoscopic cholecystectomy cases. The observed correlation between specific ultrasonographic parameters, such as gallstone size, inflammation severity, and biliary anomalies, and intraoperative challenges highlights the clinical relevance of this approach. While further research is needed to validate these findings, incorporating preoperative USG assessment could enhance surgical planning and contribute to improved patient outcomes in laparoscopic cholecystectomy.

REFERENCES
1. Joshi MR, Bohara TP, Rupakheti S, Parajuli A, Shrestha DK, Karki D, Laudari U. Pre-operative Prediction of Difficult Laparoscopic Cholecystectomy. JNMA J Nepal Med Assoc. 2015 Oct-Dec;53(200):221-226. PMID: 27746459. 2. Jalil T, Adibi A, Mahmoudieh M, Keleidari B. Could preoperative sonographic criteria predict the difficulty of laparoscopic cholecystectomy? J Res Med Sci. 2020 Jun 30;25:57. doi: 10.4103/jrms.JRMS_345_19. PMID: 33088294; PMCID: PMC7554442. 3. Gupta R, Khanduri A, Singh A, Tyagi H, Varshney R, Rawal N, Daspal U, Singh SK, Morey P, Pokharia P. Defining Critical View of Safety During Laparoscopic Cholecystectomy: The Preoperative Predictors of Failure. Cureus. 2023 Apr 12;15(4):e37464. doi: 10.7759/cureus.37464. PMID: 37187662; PMCID: PMC10181886. 4. Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system. Nassar AH, Hodson J, Ng HJ, Vohra RS, Katbeh T, Zino S, Griffiths EA. Surg Endosc. 2020;34:4549–4561. 5. Predictive factors for long operative duration in patients undergoing laparoscopic cholecystectomy after endoscopic retrograde cholangiography for combined choledochocystolithiasis. Lee R, Ha H, Han YS, Jung MK, Chun JM. Surg Laparosc Endosc Percutan Tech. 2017;27:491–496. – 6. Nassar, A. H. M., Hodson, J., Ng, H. J., Vohra, R. S., Katbeh, T., … Griffiths, E. A. (2019). Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system. Surgical Endoscopy. doi:10.1007/s00464-019-07244-5 7. Di Buono, Giuseppe, et al. "Difficult Laparoscopic Cholecystectomy and Preoperative Predictive Factors." Scientific Reports, vol. 11, no. 1, 2021, pp. 1-6, https://doi.org/10.1038/s41598-021-81938-6. 8. Randhawa, J. S. & Pujahari, A. K. Preoperative prediction of difficult lap chole: A scoring method. Indian J. Surg. 71(4), 198–201. https://doi.org/10.1007/s12262-009-0055-y (2009). 9. Urbano, D., Di Nardo, R., De Simone, P., Rossi, M., Alfani, D., & Cortesini, R. (1996). The role of preoperative investigations in predicting difficult laparoscopic cholecystectomies: Results in 200 consecutive cases. Surgical endoscopy, 10, 791-793. 10. Siddiqui, M. A., Rizvi, S. A. A., Sartaj, S., Ahmad, I., & Rizvi, S. W. A. (2017). A standardized ultrasound scoring system for preoperative prediction of difficult laparoscopic cholecystectomy. Journal of medical ultrasound, 25(4), 227-231. 11. Sakuramoto, S., Sato, S., Okuri, T., Sato, K., Hiki, Y., & Kakita, A. (2000). Preoperative evaluation to predict technical difficulties of laparoscopic cholecystectomy on the basis of histological inflammation findings on resected gallbladder. The American journal of surgery, 179(2), 114-121. 12. Santambrogio, R., Montorsi, M., Bianchi, P., Opocher, E., Schubert, L., Verga, M., ... & Spina, G. (1996). Technical difficulties and complications during laparoscopic cholecystectomy: predictive use of preoperative ultrasonography. World Journal of Surgery, 20, 978-982. 13. Fried, G. M., Barkun, J. S., Sigman, H. H., Joseph, L., Clas, D., Garzon, J., ... & Meakins, J. L. (1994). Factors determining conversion to laparotomy in patients undergoing laparoscopic cholecystectomy. The American journal of surgery, 167(1), 35-41. 14. Sugrue, M., Sahebally, S. M., Ansaloni, L., & Zielinski, M. D. (2015). Grading operative findings at laparoscopic cholecystectomy-a new scoring system. World Journal of Emergency Surgery, 10(1), 1-8. 15. Tosun, A., Hancerliogullari, K. O., Serifoglu, I., Capan, Y., & Ozkaya, E. (2015). Role of preoperative sonography in predicting conversion from laparoscopic cholecystectomy to open surgery. European journal of radiology, 84(3), 346-349.
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